Best Weight Loss Injections of 2026
Discover the most trusted telehealth providers offering GLP-1 Medications — reviewed for safety, affordability, and medical support.
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Best Overall GLP-1 Program
Why Sprout Health ranks #1:
- ✓Simple, transparent monthly pricing: $249/mo (semaglutide) or $299/mo (tirzepatide)
- ✓Price includes provider evaluation, follow-up appointments, and clinician messaging
- ✓Includes a 4-week medication supply (if prescribed) plus shipping (no hidden fees)
- ✓Month-to-month with easy cancellation before the next shipment is processed
- ✓No insurance required (they don't bill insurance)
- ✓Pricing is honored even if dosage increases (no surprise increases)
Medical Disclaimer
This content is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting any weight loss program or medication. Individual results may vary.
How GLP-1 Medications Support Weight Loss
Reviewed using published clinical research and FDA-approved prescribing guidance.
What Are GLP-1 Medications?
GLP-1 receptor agonists are prescription medications that mimic a naturally occurring hormone involved in appetite regulation and blood sugar control. When prescribed under medical supervision, they are commonly used as part of structured weight-management programs.
How They Work
These medications support weight loss through several complementary mechanisms:
- •Reduced appetite signals, helping limit hunger between meals
- •Slower gastric emptying, meaning food stays in the stomach longer
- •Increased satiety, so patients feel full sooner and for longer
Together, these effects may lead to reduced calorie intake over time.
What Clinical Studies Show
In large, well-controlled clinical trials, GLP-1–based medications such as semaglutide and tirzepatide have been associated with clinically meaningful average weight loss when used alongside lifestyle changes like diet and physical activity.
Results were observed over approximately 68–72 weeks, with outcomes varying based on medication type, dose, treatment duration, and individual response.
Important Medical Considerations
While GLP-1 medications represent a significant advancement in medical weight management, they are not appropriate for everyone.
Eligibility, dosing, and long-term treatment decisions must be determined by a licensed healthcare provider based on an individual's medical history and health profile.
Best GLP-1 For Weight Loss
Tirzepatide (Zepbound) is considered the most effective GLP-1/GIP receptor agonist for weight loss, with clinical trials showing, on average 15% to 22.5% weight loss depending on dose. Semaglutide (Wegovy/Ozempic) is another highly effective option, usually resulting in 15–16% weight loss.
- •Tirzepatide (Zepbound/Mounjaro): Often outperforms other options because it acts on two receptors (GLP-1 and GIP), offering superior weight loss (15% - 22.5% body weight) and blood sugar control.
- •Semaglutide (Wegovy/Ozempic): Highly effective and widely used. While it may result in slightly less weight loss than tirzepatide, it remains a top-tier choice for weight management.
How to Choose the Best GLP-1 Program for You
Not all GLP-1 programs are the same. The right one can mean safer care, better results, and fewer surprises.
Here are the key factors to consider before getting started:
- •Medical Oversight — Licensed clinicians review your health and determine if treatment is right for you.
- •Clear Eligibility — Upfront criteria, simple onboarding, and no confusing steps.
- •Ongoing Support — Follow-ups, progress tracking, and access to medical guidance over time.
- •Convenience — Online consultations, easy communication, and home delivery (where available).
- •Transparent Pricing — Clear costs with no hidden fees or unexpected add-ons.
Getting GLP-1 Treatment Online: What to Expect
Most leading GLP-1 programs now operate through licensed telehealth providers, allowing patients to begin treatment without in-person visits.
The process typically includes:
- •Completing a secure online health intake
- •Reviewing eligibility with a licensed healthcare provider
- •Receiving medication via home delivery or local pharmacy pickup, if prescribed
This model allows patients to access medical weight-loss treatment with professional oversight, follow-up care, and ongoing support — all remotely.
Programs vary in clinician involvement, pricing, and medication availability, which is why choosing the right provider matters.
Our Top 3 Choices
Sprout Health
- ✓All-in pricing: $249/mo (semaglutide) or $299/mo (tirzepatide)
- ✓No hidden fees, price honored even as dosage increases
Sprout Health
- ✓All-in pricing: $249/mo (semaglutide) or $299/mo (tirzepatide)
- ✓No hidden fees, price honored even as dosage increases
TrimRx
- ✓Compounded GLP-1 access starting at $199/mo
- ✓All-in pricing: med + care + delivery included
TrimRx
- ✓Compounded GLP-1 access starting at $199/mo
- ✓All-in pricing: med + care + delivery included
MEDVi
- ✓Starts at $179 for your first month (no contract)
- ✓Includes physician review + personalized plan + 1:1 guidance
MEDVi
- ✓Starts at $179 for your first month (no contract)
- ✓Includes physician review + personalized plan + 1:1 guidance
Start With Confidence
The providers featured above were selected for medical oversight, transparency, and ongoing support. If you're considering GLP-1 treatment, starting with a reputable, clinician-led program can help ensure the process is informed, safe, and aligned with your goals.
Frequently Asked Questions
Common questions about GLP-1 medications and telemedicine providers.
Sources
Jastreboff AM, Aronne LJ, Ahmad NN, et al. Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine. 2022;387(3):205–216. Average weight loss of approximately 15% to 22.5%.
† Zepbound® (tirzepatide) is a prescription-only injectable medication FDA-approved for chronic weight management in adults with obesity, or adults with overweight who have at least one weight-related medical condition. It is also approved for the treatment of moderate to severe obstructive sleep apnea in adults with obesity, and should be used in combination with a reduced-calorie diet and increased physical activity.
†† Ozempic® (semaglutide) is a prescription-only injectable medication approved by the U.S. Food and Drug Administration (FDA) for the treatment of type 2 diabetes. It is not FDA-approved for weight loss; however, weight reduction has been observed in some individuals with type 2 diabetes using the medication.
††† Mounjaro® (tirzepatide) is a prescription-only injectable medication FDA-approved for the treatment of type 2 diabetes. It is not FDA-approved for weight loss; however, weight reduction has been observed in some individuals using the medication.
†††† Wegovy® (semaglutide) is a prescription-only injectable medication FDA-approved for chronic weight management in adults with obesity, or adults with at least one weight-related medical condition, when used alongside a reduced-calorie diet and increased physical activity.
All medications require a medical evaluation and prescription from a licensed healthcare provider. Individual results may vary.